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34:770781 770 Obesity REVIEW OPEN ACCESS Clinical Trials and Investigations Comparative Efficacy of Metabolic/Bariatric Surgery Versus GLP- 1 Receptor Agonists: A Network Meta- Analysis of Randomized Controlled Trials LucasSabatella1 | PatriciaM.Ortega2 | VctorValentAzcrate1 | FernandoRotellarSastre1 | AdrianaUrizPagola1 | AhmedAhmed2 | SanjayPurkayastha2 | CarlotaTueroOjanguren1 | NuriaBlancoAsensio1 | ManuelF.Landecho3 1Obesity Unit, Department of General Surgery, Clnica Universidad de Navarra, University of Navarra, Pamplona, Spain | 2Department of Surgery and Cancer, Imperial Weight Centre, Imperial College Healthcare NHS Trust, London, UK | 3Obesity Unit, Department of Internal Medicine, Clnica Universidad de Navarra, University of Navarra, Pamplona,Spain Correspondence: Lucas Sabatella ([email protected]) Received: 23 June 2025 | Revised: 7 October 2025 | Accepted: 12 October 2025 Keywords: bariatric surger y| GLP- 1 receptor agonists| network meta- analysis| obesity treatment ABSTRACT Objective: This study compared the efficacy of metabolic/bariatric surgery (MBS) and GLP- 1 receptor agonists (GLP- 1 RAs), including dual GLP- 1/GIPanalogues, for weight and metabolic outcomes in adults with obesity